Sodium metaborate → HCID 54065558, Verbindung

HRID 744801

Reaktionsgleichung

Reaktionsgleichung von HRID 744801
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B([O-])=O.[Na+]>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][OH:14])=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 145326Sodium metaborateHCID 214586084-(Benzyloxy)-3-(3-methoxypropoxy)benzaldehyde

Produkt 1

HCID 54065558HCID 54065558, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of 31 g of 4-benzyloxy-3-(3-methoxypropyloxy)-benzaldehyde in 530 ml of ethanol/water=8:2 is added dropwise to a suspension, stirred at 0° C., of 11.74 g of sodium boranate in 530 ml of a mixture of ethanol/water=8:2. The reaction mixture is stirred for one hour at 0° C. and is then concentrated by evaporation. The residue is partitioned between diethyl ether and water. The combined organic phases are dried over sodium sulfate and concentrated by evaporation, and the residue is purified by FC (100 g of silica gel, dichloromethane/diethyl ether=1:1), yielding the title compound: Rf (dichloromethane/diethyl ether=1:1)=0.43.

Aufarbeitung

  1. concentrationis then concentrated by evaporation
  2. customThe residue is partitioned between diethyl ether and water
  3. dry with materialThe combined organic phases are dried over sodium sulfate
  4. concentrationconcentrated by evaporation
  5. customthe residue is purified by FC (100 g of silica gel, dichloromethane/diethyl ether=1:1)

Quellen und Nachweise

ORD-Eintrag
ord-185bc328f40542908d5a6b0f96ed9c7c
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05559111

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