Diisopropylethylamine → HCID 68005840, Verbindung

HRID 74482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74482
Cl[CH:2]([O:8][CH3:9])[CH2:3][Si:4]([CH3:7])([CH3:6])[CH3:5].[Br:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[C:17]([CH:19]([F:21])[F:20])[NH:16][C:15]=2[CH:22]=1.C(N(CC)C(C)C)(C)C>ClCCl>[Br:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[C:17]([CH:19]([F:20])[F:21])[N:16]([CH2:9][O:8][CH2:2][CH2:3][Si:4]([CH3:7])([CH3:6])[CH3:5])[C:15]=2[CH:22]=1

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 647235395-bromo-2-(difluoromethyl)-1H-1,3-benzodiazoleHCID 87805942(2-Chloro-methoxy-ethyl)-trimethyl-silane

Produkt 1

HCID 68005840HCID 68005840, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(2-Chloro-methoxy-ethyl)-trimethyl-silane (1.1 ml, 6.4 mmol, 1.5 eq.) was added to an anhydrous dichloromethane solution (22 ml) of 6-bromo-2-difluoromethyl-1H-benzimidazol (1.0 g, 4.27 mmol) and N,N-diisopropyl ethyl amine (1.9 ml, 10.6 mmol, 2.5 eq.). This was stirred at room temperature for 18 hours. The reaction mixture was concentrated. The residue obtained by concentration under reduced pressure was purified by silica gel column chromatography. Thus, 6-bromo-2-difluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazole was obtained as a yellow solid (1.37 g, 85%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue obtained by concentration under reduced pressure
  3. customwas purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-376e286b8d604fb5ad3897ccec8a0208
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829199B2

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