Maleic Acid → T-817 maleate

HRID 7451

Reaktionsgleichung

Reaktionsgleichung von HRID 7451
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25]>CC(C)=O>[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 444266Maleic AcidHCID 9901946Edonerpic

Produkt 1

HCID 11338749T-817 maleateAusbeute 88,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

In 56 mL of acetone was dissolved 8.00 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, followed by adding thereto 3.19 g of maleic acid, and the resulting mixture was heated at 60° C. to effect dissolution. The reaction mixture was slowly cooled and then stirred at 5° C. for 30 minutes. The crystals precipitated were collected by filtration to obtain 9.89 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate as colorless crystals.

Aufarbeitung

  1. additionby adding
  2. dissolutiondissolution
  3. temperatureThe reaction mixture was slowly cooled
  4. customThe crystals precipitated
  5. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-dbe896ef33d741a789d2585a245fe8e0
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087594B2

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