Diisopropylethylamine → HCID 58386728, Verbindung

HRID 74510

Reaktionsgleichung

Reaktionsgleichung von HRID 74510
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.CCN(C(C)C)C(C)C.[NH:20]1[CH:28]2[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]2)[CH2:22][CH2:21]1>ClCCl>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([N:20]2[CH:28]3[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:22][CH2:21]2)=[O:9])[CH:3]=1

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 107275Octahydro-1H-indoleHCID 184220986-Chloropyrimidine-4-carbonyl chloride

Produkt 1

HCID 58386728HCID 58386728, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel3×

Versuchsvorschrift

0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.

Aufarbeitung

  1. extractionextracted with water
  2. customThe organic phase was separated off
  3. customdried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down i
  6. customand dried

Quellen und Nachweise

ORD-Eintrag
ord-d9e6d1a79cb5434b9b413788f1e27a35
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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