2-Amino-8-hydroxynaphthalene-6-sulfonic acid → 4-Hydroxy-6-p-nitrobenzenesulfonamido-2-naphthalenesulfonic acid sodium salt

HRID 745136

Reaktionsgleichung

Reaktionsgleichung von HRID 745136
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([OH:15])(=[O:14])=[O:13])[CH:6]=[C:5]2[OH:16].[OH-].[Na+:18].O.O.O.C([O-])(=O)C.[Na+].[N+:27]([C:30]1[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=1)([O-:29])=[O:28]>O>[Na+:18].[OH:16][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([NH:1][S:36]([C:33]3[CH:32]=[CH:31][C:30]([N+:27]([O-:29])=[O:28])=[CH:35][CH:34]=3)(=[O:37])=[O:38])[CH:3]=2)[CH:8]=[C:7]([S:12]([O-:15])(=[O:13])=[O:14])[CH:6]=1

Komponenten

6

Edukt 4

HCID 70222-Amino-8-hydroxynaphthalene-6-sulfonic acidHCID 74044-Nitrobenzenesulfonyl chlorideHCID 14798Sodium HydroxideHCID 23665404Sodium Acetate Trihydrate

Produkt 1

HCID 886742654-Hydroxy-6-p-nitrobenzenesulfonamido-2-naphthalenesulfonic acid sodium salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of 11.95 g of 6-amino-4-hydroxy-2-naphthalenesulfonic acid in 200 ml of water was adjusted to pH 8.0 with aqueous 5N sodium hydroxide, then 12.17 g of sodium acetate trihydrate was added to the stirred mixture followed by 15.06 g of p-nitrobenzenesulfonyl chloride. The mixture was stirred vigorously under nitrogen at room temperature for 16 hours producing a yellow solid. The mixture was filtered and the solid was washed with water, ethanol and then ether and dried in vacuo and gave 12.07 g of 4-hydroxy-6-p-nitrobenzenesulfonamido-2-naphthalenesulfonic acid sodium salt as a yellow solid.

Aufarbeitung

  1. customproducing a yellow solid
  2. filtrationThe mixture was filtered
  3. washthe solid was washed with water, ethanol
  4. dry with materialether and dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1626457b799f4f0eb3a77280f3ea3936
Quelldatensatz
uspto-grants-1986_07
Patentnummer
USH0000083

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