Water → HCID 58386508, Verbindung

HRID 74522

Reaktionsgleichung

Reaktionsgleichung von HRID 74522
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][CH2:17][C:18]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=O)=[CH:8]1.O>C1COCC1>[N:20]1([CH2:18][CH2:17][CH2:16][C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][CH:8]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 48067833-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-oneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 58386508HCID 58386508, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Under a nitrogen atmosphere 3.40 mL (3.40 mmol) of a 1M lithium aluminium hydride solution in THF was slowly added dropwise to 670 mg (2.77 mmol) 3-(1H-indol-3-yl)-1-pyrrolidin-1-yl-propan-1-one in 30 mL THF. The reaction mixture was stirred for 1 h at 65 C and after cooling combined with 1 mL water. After 10 min stirring at RT the organic phase was dried on sodium sulphate and evaporated down i. vac. The product was reacted further without any further purification.

Aufarbeitung

  1. temperatureafter cooling
  2. stirringAfter 10 min stirring at RT the organic phase
  3. customwas dried on sodium sulphate
  4. customevaporated down i
  5. customThe product was reacted further without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-39f6eb522e4e4be3be7652d682775701
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

Verknüpfte Notizen

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