Sodium Hydroxide → 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine

HRID 745485

Reaktionsgleichung

Reaktionsgleichung von HRID 745485
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13]Cl)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.[OH-].[Na+]>CCOCC>[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:13][CH:12]([CH3:15])[CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=2)[CH2:19][CH2:18]1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

Produkt 1

HCID 132519811-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazineAusbeute 93,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

533 g of 3-(4-tert.butylphenyl)-2-methylpropyl chloride and 714 g of 4-methylpiperazine were stirred for 7 hours at 140° C. and then cooled to +10° C. in an ice bath, and 400 ml of 50% strength sodium hyroxide solution were added slowly, followed by the addition of 500 ml of ether. The organic phase was separated off, dried over sodium hydroxide and distilled to give 640 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine of boiling point 135°-140° C./0.3 mbar.

Aufarbeitung

  1. temperaturecooled to +10° C. in an ice bath
  2. customThe organic phase was separated off
  3. dry with materialdried over sodium hydroxide
  4. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-8bdee9547f6c4f59aa42d2195697c970
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04599335

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