Ethanolamine → 3-(2-Aminoethoxy)-6-chloropyridazine hydrochloride

HRID 745502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 745502
[H-].[Na+].[NH2:3][CH2:4][CH2:5][OH:6].[Cl:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>C1C=CC=CC=1>[ClH:7].[NH2:3][CH2:4][CH2:5][O:6][C:11]1[N:10]=[N:9][C:8]([Cl:7])=[CH:13][CH:12]=1

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 24758Sodium hydrideHCID 673313,6-Dichloropyridazine

Produkt 1

HCID 233135663-(2-Aminoethoxy)-6-chloropyridazine hydrochlorideAusbeute 54,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a suspension of 4.2 g of 61% sodium hydride in 100 ml of benzene was added dropwise 6.2 g of 2-aminoethanol at room temperature. Then, 15 g of 3,6-dichloropyridazine was added, and the mixture was refluxed for 1 hour. After cooling, the reaction mixture was washed with water, and dried over magnesium sulfate. After evaporating the solvent, the residue was treated with hydrogen chrolide-ether solution to give 5.73 g of 3-(2-aminoethoxy)-6-chloropyridazine hydrochloride as crystals.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 1 hour
  2. temperatureAfter cooling
  3. washthe reaction mixture was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customAfter evaporating the solvent
  6. additionthe residue was treated with hydrogen chrolide-ether solution

Quellen und Nachweise

ORD-Eintrag
ord-5c6ef1edb3be4f9d8326bfb04e2e20ab
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04599333

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