3,6-Dichloropyridazine → 1-(2-Methylphenoxy)-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylamino)ethylamino]-2-propanol

HRID 745509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 745509
[CH3:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][CH2:5][CH:6]([OH:14])[CH2:7][NH:8][C:9]([CH3:13])([CH3:12])[CH2:10][NH2:11].[Cl:19][C:20]1[N:21]=[N:22][C:23](Cl)=[CH:24][CH:25]=1>C1C=CC=CC=1>[CH3:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][CH2:5][CH:6]([OH:14])[CH2:7][NH:8][C:9]([CH3:13])([CH3:12])[CH2:10][NH:11][C:23]1[N:22]=[N:21][C:20]([Cl:19])=[CH:25][CH:24]=1

Komponenten

4

Edukt 2

HCID 673313,6-DichloropyridazineHCID 100607882-Propanol, 1-[(2-amino-1,1-dimethylethyl)amino]-3-(2-methylphenoxy)-

Produkt 1

HCID 100217191-(2-Methylphenoxy)-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylamino)ethylamino]-2-propanolAusbeute 67,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To 1.58 g of 1-(2-methylphenoxy)-3-(1,1-dimethyl-2-aminoethylamino)-2-propanol heated at 110° C. in an oil bath with stirring was added 934 mg of 3,6-dichloropyridazine little by little. After heating at 110° C. for 1 hour, the reaction mixture was dissolved in benzene, and extracted with 1N hydrochloric acid. The aqueous layer was made alkaline with potassium carbonate, and extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated to give 1.55 g of 1-(2-methylphenoxy)-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylamino)ethylamino]-2-propanol as an oil.

Aufarbeitung

  1. extractionextracted with 1N hydrochloric acid
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-10f16b323fc24e5990ae31f32d0b0969
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04599333

Notizen zur Reaktion

Wird geladen…