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Ethanol → 2-(4-Fluorophenyl)-2-methylbutyl alcohol

HRID 745633
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 745633
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:14])([CH2:12][CH3:13])[C:9](O)=[O:10])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(O)C.O>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:14])([CH2:12][CH3:13])[CH2:9][OH:10])=[CH:6][CH:7]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 702EthanolHCID 962WaterHCID 137117812-(4-Fluorophenyl)-2-methylbutanoic acidHCID 21226445Aluminium lithium hydride2×

Produkt 1

HCID 155826502-(4-Fluorophenyl)-2-methylbutyl alcoholAusbeute 93,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028
Tetrahydrofuran
Lösungsmittel
2×

Versuchsvorschrift

A solution of 3.0 g of 2-(4-fluorophenyl)-2-methylbutyric acid in 10 ml of tetrahydrofuran was added dropwise to a mixture of 20 ml of tetrahydrofuran and 0.5 g of lithium aluminum hydride at 40° C. The temperature was then elevated and the mixture was refluxed for 30 minutes. The mixture was cooled to room temperature and ethanol was added dropwise to the mixture to decompose excessive lithium aluminum hydride. Then, water was added to the mixture to complete the decomposition. The formed precipitate was removed by filtration and tetrahydrofuran was removed from the filtrate by distillation under reduced pressure. The residue was extracted with benzene, and the benzene extract was washed with water, dried over Na2SO4, and evaporated under reduced pressure to give 2.6 g of 2-(4-fluorophenyl)-2-methylbutyl alcohol.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 30 minutes
  2. customThe formed precipitate was removed by filtration and tetrahydrofuran
  3. customwas removed from the filtrate by distillation under reduced pressure
  4. extractionThe residue was extracted with benzene
  5. extractionthe benzene extract
  6. washwas washed with water
  7. dry with materialdried over Na2SO4
  8. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3fbdfeb6f00a47859f5552fc34b23d24
Quelldatensatz
uspto-grants-1986_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04599362

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