Phthalic Anhydride → Fluorescein phthalamic acid

HRID 745849

Reaktionsgleichung

Reaktionsgleichung von HRID 745849
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]2[C:8]([O:10][C:11]3([C:21]4[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:20]=4[O:19][C:13]4[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:12]3=4)[C:3]=2[CH:2]=1)=[O:9].[C:27]1(=[O:37])[O:32][C:30](=[O:31])[C:29]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:28]12>C(O)(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[C:3]([C:11]2[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=3[O:19][C:20]3[C:21]=2[CH:22]=[CH:23][C:24]([CH:25]=3)=[O:26])[CH:2]=1.[C:27]([OH:32])(=[O:37])[C:28]1[C:29](=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:30]([NH2:7])=[O:31]

Komponenten

4

Edukt 2

HCID 6811Phthalic AnhydrideHCID 768455-Aminofluorescein

Produkt 1

HCID 131714783Fluorescein phthalamic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 350 mg (0.001 mol) of 5-aminofluorescein and 200 mg of phthalic anhydride in 5 milliliters of glacial acetic acid was stirred at ambient temperature for 48 hours. The yellow reddish product was filtered and washed once with acetic acid and twice with diethyl ether. 460 Mg of fluorescein-phthalamic acid was obtained. I.R (KBR) showed bands at 3060; 3000; 1685; 1590; 1540; 1480; 1460; 1430; 1350; 1310; 1270; 1230; 1195; 1150; and 1115 cm-1.

Aufarbeitung

  1. filtrationThe yellow reddish product was filtered
  2. washwashed once with acetic acid and twice with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-7cbb0db406bd487cad6863495797162b
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04600775

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