Hydrazine hydrate (1:1) → HCID 13656051, Verbindung

HRID 745931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 745931
[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11](=O)[CH:10]([CH2:16][C:17]([OH:19])=O)[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:21][NH2:22]>C(O)C>[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11]2=[N:21][NH:22][C:17](=[O:19])[CH2:16][CH:10]2[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 13656050[5-(1H-Imidazol-1-yl)-1-oxo-2,3-dihydro-1H-inden-2-yl]acetic acid

Produkt 1

HCID 13656051HCID 13656051, VerbindungAusbeute 48 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 1.48 g of 2,3-dihydro-5-(1H-imidazol-1-yl)-1-oxo-1H-indene-2-acetic acid and 0.38 g of 85% hydrazine hydrate in 15 ml of ethanol is heated to reflux for three hours. The reaction mixture is filtered, the residue is washed with ethanol and purified by crystallization from ethanol to give 0.7 g of the product, 2,4,4a,5-tetrahydro-7-(1H-imidazol-1-yl)-3H-indeno[1,2-c]pyridazin-3-one, mp 263°-264° dec.

Aufarbeitung

  1. temperatureto reflux for three hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed with ethanol
  4. custompurified by crystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e0e5d4a25264406f8fcb0cc7bc50efba
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04602019

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