HCID 11616834, Verbindung → HCID 11602341, Verbindung
Reaktionsgleichung
[F:1][C:2]1[C:3]([C:8]([C:10]2[C:11]3[CH:23]=[CH:22][CH:21]=[CH:20][C:12]=3[S:13][C:14]=2[CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[CH2:9])=[N:4][CH:5]=[CH:6][CH:7]=1>C(O)C.[Pt](=O)=O>[F:1][C:2]1[C:3]([CH:8]([C:10]2[C:11]3[CH:23]=[CH:22][CH:21]=[CH:20][C:12]=3[S:13][C:14]=2[CH2:15][CH2:16][N:17]([CH3:18])[CH3:19])[CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of (2-{3-[1-(3-fluoro-pyridin-2-yl)-vinyl]-benzo[b]thiophen-2-yl}-ethyl)-dimethyl-amine (Compound 18-2) (26 mg, 0.080 mmol) in ethanol (1 mL), platinum dioxide (9 mg, 0.04 mol) was added. The reaction was shaken at 30 psi for 4 hours under H2 atmosphere and monitored by LC/MS. The reaction was filtered and washed with EtOH and subsequently purified by mass triggered preparative HPLC to afford (2-{3-[1-(3-fluoro-pyridin-2-yl)-ethyl]-benzo[b]thiophen-2-yl}-ethyl)-dimethyl-amine (Compound 18-3). MH+=329. tR=4.7 min (Method 2).