2,3-Dihydroxybutanedioic Acid → (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate

HRID 746657

Reaktionsgleichung

Reaktionsgleichung von HRID 746657
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.[C:25]([OH:34])(=[O:33])[CH:26]([CH:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1.[CH:26]([OH:27])([C:25]([OH:34])=[O:33])[CH:28]([OH:29])[C:30]([OH:32])=[O:31]

Komponenten

3

Edukt 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 443879Tolterodine

Produkt 1

HCID 9847786(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate

Versuchsvorschrift

In accordance with the present invention, a process is provided for preparation of tolterodine tartrate form I. Thus, tolterodine free base is dissolved in a suitable solvent, tartaric acid is added to the solution and tolterodine tartrate form I is isolated. The suitable solvents are ethanol, methylene dichloride, chloroform, acetone, acetonitrile and 1,4-dioxane; and a mixture thereof. The preferable solvents are ethanol and acetone.

Aufarbeitung

  1. additionis added to the solution

Quellen und Nachweise

ORD-Eintrag
ord-ebd5bcaa267240eda38180859602b694
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393874B2

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