Hydrochloric Acid → (2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanol

HRID 747604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 747604
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])=[O:12])([O-])=O.[Sn].Cl>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])[OH:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 68569266(2-Nitro-5-fluorophenyl)(2-chlorophenyl)methanone

Produkt 1

HCID 68567746(2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanolAusbeute 100,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 0.5 g of (2-nitro-5-fluorophenyl)(2-chlorophenyl)methanone dissolved in 10 ml of ethanol are added 0.44 g of tin and 1.5 ml of 12M hydrochloric acid, and the mixture is left for 3 hours at room temperature. The reaction medium is concentrated and the residue is taken up in ethyl acetate and washed with 2M sodium hydroxide solution and then with saturated ammonium chloride solution. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 0.453 g of the expected product.

Aufarbeitung

  1. concentrationThe reaction medium is concentrated
  2. washwashed with 2M sodium hydroxide solution
  3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a38e9f99595b444aaffe62b79dc614b5
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396958B2

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