1H-1,2,4-Triazole → 1-(4-Fluorobenzyl)-1H-1,2,4-triazole

HRID 748055

Reaktionsgleichung

Reaktionsgleichung von HRID 748055
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1.N12CCCN=C1CCCCC2>C1COCC1>[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:9][CH:8]=1

Komponenten

5

Edukt 3

HCID 92571H-1,2,4-TriazoleHCID 680214-Fluorobenzyl bromideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Produkt 1

HCID 232736751-(4-Fluorobenzyl)-1H-1,2,4-triazoleAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of 1,2,4-triazole (0.803 g, 11.6 mmol) in THF (100 mL) at 0° C. was added 4-fluorobenzyl bromide (2.0 g, 10.6 mmol), then 1,8-diazabicyclo[5.4.0]undec-7-ene (1.9 mL, 12.7 mmol) and the mixture was slowly warmed to room temperature. The solution was concentrated in vacuo, then purified by column chromatography (SiO2, MeOH/EtOAc, 5:95) to yield a white solid in 68% yield.

Aufarbeitung

  1. concentrationThe solution was concentrated in vacuo
  2. custompurified by column chromatography (SiO2, MeOH/EtOAc, 5:95)
  3. customto yield a white solid in 68% yield

Quellen und Nachweise

ORD-Eintrag
ord-783f10cb83564fa286b18b2076bcaec6
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07399778B2

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