1H-1,2,4-Triazole → 1-(4-Methoxybenzyl)-1,2,4-triazole

HRID 748061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 748061
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[CH:10][CH:9]=1.C1CCN2C(=NCCC2)CC1>C1COCC1>[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 92571H-1,2,4-TriazoleHCID 699934-Methyloxybenzyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Produkt 1

HCID 108453281-(4-Methoxybenzyl)-1,2,4-triazoleAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 1,2,4-triazole (2.0 g, 29 mmol) in THF (80 mL) at 0° C. was added 4-methoxybenzyl chloride (4.0 mL, 29 mmol) and DBU (5.20 mL, 34.7 mmol). The reaction mixture was warmed to room temperature and allowed to stir overnight. The solution was filtered and the filtrate was concentrated. The resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9) to give 3.12 g (57%) of 1-(4-methoxybenzyl)-1H-1,2,4-triazole as a colorless oil.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9)

Quellen und Nachweise

ORD-Eintrag
ord-ad67110a16d7408c8de6eff2bf355f35
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07399778B2

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