Dichloromethane → HCID 23114554, Verbindung

To a methylene chloride solution (20 ml) of the 4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridine (221 mg, 0.58 mmol) obtained in Example 142 was added 3-chloroperbenzoic acid (100 mg, 0.58 mmol) and the mixture was stirred for 20 hours. The reaction mixture was diluted with ether (60 ml), followed by washing with a saturated aqueous solution of sodium bicarbonate, water and brine. The solution was dried and then filtered. The filtrate was then concentrated under reduced pressure. The residue thus obtained was subjected to silica gel chromatography (ethyl acetate) to yield the title compound (183 mg, 80%). The compound was then crystallized from ethanol and obtained as colorless needle crystals.

1. washby washing with a saturated aqueous solution of sodium bicarbonate, water and brine
2. customThe solution was dried
3. filtrationfiltered
4. concentrationThe filtrate was then concentrated under reduced pressure
5. customThe residue thus obtained

ORD-Eintrag

ord-c1cd28a387454d60b3fbd7956f4f59b5

Quelldatensatz

uspto-grants-2008_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07399775B2