Toluene → 2-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one

HRID 749225

Reaktionsgleichung

Reaktionsgleichung von HRID 749225
[Br:1]Br.[CH2:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=1)[CH:4]([CH3:6])[CH3:5].C1(C)C=CC=CC=1>C(O)C>[Br:1][CH2:14][C:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:3][CH:4]([CH3:6])[CH3:5])=[CH:12][CH:11]=1)=[O:15]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 24408BromineHCID 932144'-Isobutylacetophenone

Produkt 1

HCID 136563372-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-oneAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Bromine (1.25 ml; 25 mmol) is added dropwise to a solution of 4′-isobutylacetophenone (3.52 g; 20 mmol) in 60 ml of ethanol cooled down to approximately 5° C. After stirring the reaction mixture for 30 minutes at this temperature, stirring is continued for one hour at ambient temperature. The reaction medium, to which small portions of toluene are added, is concentrated to dryness. After purification on a silica column (eluent: ethyl-heptane acetate: 5-95), a colourless oil is obtained with a yield of 57%.

Aufarbeitung

  1. stirringstirring
  2. waitis continued for one hour at ambient temperature
  3. concentrationis concentrated to dryness
  4. customAfter purification on a silica column (eluent: ethyl-heptane acetate: 5-95)
  5. customa colourless oil is obtained with a yield of 57%

Quellen und Nachweise

ORD-Eintrag
ord-37cffd1cac174c97ae12e2ea559231b3
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402602B2

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