Tetrahydrofuran → N-[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]piperidine-4-carboxamide bishydrochloride

Reaktionsgleichung

[C@H:1]1(N)[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]1[NH2:7].[Cl:9]C1C=C2C(B3OC(C)(C)C(C)(C)O3)=CN(S(C3C=CC(C)=CC=3)(=O)=O)C2=[N:14]C=1.CC[N:40]([CH:44]([CH3:46])C)[CH:41]([CH3:43])C.[Cl:47][C:48]1[CH:49]=[C:50]2[C:56]([C:57]3[N:62]=[C:61](S(C)=O)[C:60]([F:66])=[CH:59][N:58]=3)=[CH:55][N:54](S(C3C=CC(C)=CC=3)(=O)=O)[C:51]2=[N:52][CH:53]=1.C1C[O:80][CH2:79][CH2:78]1>>[ClH:9].[ClH:47].[Cl:47][C:48]1[CH:49]=[C:50]2[C:56]([C:57]3[N:58]=[C:59]([NH:7][C@H:2]4[CH2:1][CH2:6][CH2:5][C@@H:4]([NH:14][C:79]([CH:78]5[CH2:43][CH2:41][NH:40][CH2:44][CH2:46]5)=[O:80])[CH2:3]4)[C:60]([F:66])=[CH:61][N:62]=3)=[CH:55][NH:54][C:51]2=[N:52][CH:53]=1