3-Aminopyridine → ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluoroanilino)benzoyl]-3-(pyridin-3-ylamino)prop-2-enoate

HRID 749488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 749488
[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[C:17]([NH:21][C:22]2[C:27]([F:28])=[CH:26][C:25]([F:29])=[CH:24][C:23]=2[Cl:30])=[CH:16][C:3]=1[C:4]([C:6](=[CH:12][N:13](C)[CH3:14])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].N[C:32]1[CH:33]=[N:34][CH:35]=C[CH:37]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[C:17]([NH:21][C:22]2[C:27]([F:28])=[CH:26][C:25]([F:29])=[CH:24][C:23]=2[Cl:30])=[CH:16][C:3]=1[C:4]([C:6](=[CH:12][NH:13][C:14]1[CH:35]=[N:34][CH:33]=[CH:32][CH:37]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

Komponenten

4

Edukt 2

HCID 100093-AminopyridineHCID 68796206Ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoyl]-3-dimethylaminoacrylate

Produkt 1

HCID 178471940ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluoroanilino)benzoyl]-3-(pyridin-3-ylamino)prop-2-enoateAusbeute 104,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 30 mg (0.06 mmol) of ethyl 2-[2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino) benzoyl]-3-dimethylaminoacrylate and 15 mg (0.16 mmol) of 3-aminopyridine in 2 ml of toluene were heated at 150° C. for 7 hours. Concentration resulted in 33 mg of the desired product, which were employed without further purification in the next stage.

Aufarbeitung

  1. concentrationConcentration

Quellen und Nachweise

ORD-Eintrag
ord-c37c822198a648f091a061bbc8acbaa4
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402674B2

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