Hydrochloric Acid → HCID 67286541, Verbindung

HRID 75019

Reaktionsgleichung

Reaktionsgleichung von HRID 75019
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>O=[Pt]=O>[NH2:11][CH:10]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH:2]1[OH:1]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68073-Nitrosalicylic acid

Produkt 1

HCID 67286541HCID 67286541, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 345198Adams' catalystKatalysator

Versuchsvorschrift

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with hot H2O
  3. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-fe8427b0b8d8469c82886b32f6cd2244
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829007B2

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