Water → HCID 21874759, Verbindung

HRID 750540Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 750540
[NH2:1][C:2]1[N:3]=[C:4]([C:25]2[O:26][CH:27]=[CH:28][CH:29]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19](=O)[O:20]CC)=[C:14]([CH3:24])[CH:13]=3)[C:6]=2[N:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+].O>C1COCC1>[NH2:1][C:2]1[N:3]=[C:4]([C:25]2[O:26][CH:27]=[CH:28][CH:29]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][CH:19]=[O:20])=[C:14]([CH3:24])[CH:13]=3)[C:6]=2[N:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 10135175HCID 10135175, VerbindungHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 21874759HCID 21874759, VerbindungAusbeute 7,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of ethyl 4-((5-amino-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-3-yl)methyl)-2-methylphenylcarbamate (318 mg, 0.81 mmol) and LiAlH4 (62 mg, 1.62 mmol) in dry THF (30 mL) was refluxed overnight, cooled to room temperature, treated with 13% aqueous NaOH solution (0.1 mL) then water (0.3 mL), stirred for 30 min, filtered through Celite and concentrated in vacuo. The resulting solid was triturated with THF and filtered to give the title compound (20 mg, 7%) as a yellow solid.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. filtrationfiltered through Celite
  3. concentrationconcentrated in vacuo
  4. customThe resulting solid was triturated with THF
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-7b135f49b65a428aab51465b0108100a
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405219B2

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