Oxalyl chloride → 7-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

HRID 75084Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 75084
[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16](O)=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3].C(Cl)(=O)C([Cl:23])=O>C1(C)C=CC=CC=1>[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16]([Cl:23])=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 206800246-Methacryloyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-7-carboxylic Acid

Produkt 1

HCID 866409437-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Suspended into 135 mL of toluene was 18.0 g of the carboxylic acid (26) obtained in Synthesis Example 1-1-2, and then into the resulting suspension was gradually added 10.3 g of oxalyl chloride at 80° C. After this mixture was stirred for 4 hours, toluene was removed by distillation under reduced pressure to obtain the intended product. The obtained acid chloride was used in the next reaction without further purification.

Aufarbeitung

  1. customobtained in Synthesis Example 1-1-2
  2. customat 80° C
  3. customtoluene was removed by distillation under reduced pressure
  4. customto obtain the intended product

Quellen und Nachweise

ORD-Eintrag
ord-fe22ae6ffcae43baacdaa4e45626e590
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835097B2

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