1-Iodo-4-(trifluoromethoxy)benzene → 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide

HRID 751220

Reaktionsgleichung

Reaktionsgleichung von HRID 751220
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:10][C:11]([NH:13][CH2:14][C:15]#[CH:16])=[O:12])[CH:8]=2)[CH:3]=[CH:2]1.[F:17][C:18]([F:28])([F:27])[O:19][C:20]1[CH:25]=[CH:24][C:23](I)=[CH:22][CH:21]=1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:10][C:11]([NH:13][CH2:14][C:15]#[C:16][C:23]3[CH:22]=[CH:21][C:20]([O:19][C:18]([F:17])([F:27])[F:28])=[CH:25][CH:24]=3)=[O:12])[CH:8]=2)[CH:3]=[CH:2]1

Komponenten

3

Edukt 2

HCID 27772941-Iodo-4-(trifluoromethoxy)benzeneHCID 860955052-(1H-Indol-6-yl)-N-prop-2-ynyl-acetamide

Produkt 1

HCID 688256642-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide

Versuchsvorschrift

In analogy to the procedure described for example 8 a], 2-(1H-indol-6-yl)-N-prop-2-ynyl-acetamide was reacted with 4-(trifluoromethoxy)-iodobenzene in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as colorless crystals.

Quellen und Nachweise

ORD-Eintrag
ord-2d278a71bb944401bfba164c31f4be3d
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405236B2

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