Lithium Hydroxide → (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid

HRID 751222Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 751222
C([O:3][C:4](=[O:33])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][C:16](=[O:32])[NH:17][CH2:18][C:19]#[C:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[F:30][C:28]([F:29])([F:31])[O:27][C:24]1[CH:23]=[CH:22][C:21]([C:20]#[C:19][CH2:18][NH:17][C:16]([CH2:15][C:12]2[CH:13]=[C:14]3[C:9]([CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:33])=[O:3])=[CH:10][CH:11]=2)=[O:32])=[CH:26][CH:25]=1

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 68822191(6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester

Produkt 1

HCID 68822499(6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid

Versuchsvorschrift

In analogy to the procedure described for example 1 e], (6-{[3-(4-trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester was treated with LiOH to obtain the title compound as off-white solid.

Quellen und Nachweise

ORD-Eintrag
ord-519d81932a874eeca4167d70a18245d7
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405236B2

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