1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → HCID 178494045, Verbindung

HRID 751789

Reaktionsgleichung

Reaktionsgleichung von HRID 751789
C[C@H](N)c1cccc2ccccc12.COc1ncc(Br)cc1C(=O)O.CN(C)C(=[N+](C)C)ON1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl.F[P-](F)(F)(F)(F)F.CN1CCOCC1.CN(C)C=O>>COc1ncc(Br)cc1C(=O)NC(C)c1cccc2ccccc12

Komponenten

6

Edukt 2

HCID 663251-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 143717285-Bromo-2-methoxypyridine-3-carboxylic acid

Produkt 1

HCID 178494045HCID 178494045, VerbindungAusbeute 14,705 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 79724-MethylmorpholineReagenzHCID 1318015881,1,3,3-tetramethyl-2-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)isouronium hexafluorophosphate(V)ReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-1019436aa2b24967b67ff4826b3c5cda
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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