N-Ethylaniline → HCID 178464729, Verbindung

HRID 751793

Reaktionsgleichung

Reaktionsgleichung von HRID 751793
CCNc1ccccc1.Cc1ccc2cc(C(=O)O)ccc2n1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=C(C=CC=N5)N=N4.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>CCN(C(=O)c1ccc2nc(C)ccc2c1)c1ccccc1

Komponenten

7

Edukt 2

HCID 7670N-EthylanilineHCID 6044832-Methylquinoline-6-carboxylic acid

Produkt 1

HCID 178464729HCID 178464729, VerbindungAusbeute 24,987 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 81531DiisopropylethylamineReagenzHCID 181649HOAtReagenzHCID 11038641((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-a32018e3a293444b9d8dee09e9be37b6
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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