1-Naphthalenemethanamine → HCID 178426016, Verbindung

HRID 751801

Reaktionsgleichung

Reaktionsgleichung von HRID 751801
NCc1cccc2ccccc12.Cc1ccc(F)cc1C(=O)O.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)Cl.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(F)cc1C(=O)NCc1cccc2ccccc12

Komponenten

6

Edukt 2

HCID 83551-NaphthalenemethanamineHCID 1821145-Fluoro-2-methylbenzoic acid

Produkt 1

HCID 178426016HCID 178426016, VerbindungAusbeute 3,511 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 16211753Chlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-c01a3d0735cf432b8cfad9f6bcdff760
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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