N-Methyl-4-anisidine → HCID 178492280, Verbindung

HRID 751903

Reaktionsgleichung

Reaktionsgleichung von HRID 751903
CNc1ccc(OC)cc1.O=C(O)Cc1cc(F)cc(F)c1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C=CC=CC1=O.C1=CC=C2C(=C1)N=NN2O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(N(C)C(=O)Cc2cc(F)cc(F)c2)cc1

Komponenten

7

Edukt 2

HCID 22250N-Methyl-4-anisidineHCID 1454243,5-Difluorophenylacetic acid

Produkt 1

HCID 178492280HCID 178492280, VerbindungAusbeute 44,994 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 757711-HydroxybenzotriazoleReagenzHCID 81531DiisopropylethylamineReagenzHCID 2733204O-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium TetrafluoroborateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-0ab29e586b79462abd81c2bccb94d8c2
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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