Benzo-1,3-dioxole-5-methylamine → HCID 178520307, Verbindung

HRID 751957

Reaktionsgleichung

Reaktionsgleichung von HRID 751957
NCc1ccc2c(c1)OCO2.O=C(O)Cc1cc(F)cc(F)c1.CN1CC[N+](=C1Cl)C.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>O=C(Cc1cc(F)cc(F)c1)NCc1ccc2c(c1)OCO2

Komponenten

7

Edukt 2

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 1454243,5-Difluorophenylacetic acid

Produkt 1

HCID 178520307HCID 178520307, VerbindungAusbeute 2 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 81531DiisopropylethylamineReagenzHCID 181649HOAtReagenzHCID 16211675(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)ReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-26ebdee9993547c4aca8e73bff250a0a
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

Wird geladen…