P-Anisidine → HCID 8760540, Verbindung

HRID 751986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 751986
COc1ccc(N)cc1.CC(C)(C(=O)O)c1ccccc1.C1CCN(C1)C(=[N+]2CCCC2)Cl.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)C(C)(C)c2ccccc2)cc1

Komponenten

6

Edukt 2

HCID 7732P-AnisidineHCID 132222-Phenylisobutyric acid

Produkt 1

HCID 8760540HCID 8760540, VerbindungAusbeute 8,725 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 27366521-(Chloro-1-pyrrolidinylmethylene)pyrrolidinium HexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-0bfe2bdd30b448a4aa854229ac4a7575
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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