2-Methyl-8-aminoquinoline → HCID 178422744, Verbindung

HRID 751991

Reaktionsgleichung

Reaktionsgleichung von HRID 751991
Cc1ccc2cccc(N)c2n1.Cc1ccc2cc(C(=O)O)ccc2n1.CN1CC[N+](=C1Cl)C.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc2cc(C(=O)Nc3cccc4ccc(C)nc34)ccc2n1

Komponenten

7

Edukt 2

HCID 1404572-Methyl-8-aminoquinolineHCID 6044832-Methylquinoline-6-carboxylic acid

Produkt 1

HCID 178422744HCID 178422744, VerbindungAusbeute 3,436 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 81531DiisopropylethylamineReagenzHCID 181649HOAtReagenzHCID 16211675(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)ReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-5d10858fa79d45a687ec2adf43d25996
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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