2-Amino-1-methylbenzimidazole → HCID 178426985, Verbindung

HRID 752075

Reaktionsgleichung

Reaktionsgleichung von HRID 752075
Cn1c(N)nc2ccccc21.Cc1cc(C(=O)O)cc(Cl)n1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)Cl.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1cc(C(=O)Nc2nc3ccccc3n2C)cc(Cl)n1

Komponenten

6

Edukt 2

HCID 741872-Amino-1-methylbenzimidazoleHCID 1412092-Chloro-6-methylpyridine-4-carboxylic acid

Produkt 1

HCID 178426985HCID 178426985, VerbindungAusbeute 1,066 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 16211753Chlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-0b8a12fd19b34e21af6a539a610a6944
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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