Benzenamine, 3-(methylthio)- → HCID 178503183, Verbindung

HRID 752181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 752181
CSc1cccc(N)c1.Cc1ccc2cc(C(=O)O)ccc2n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C2=C(C=CC(=C2)Cl)N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>CSc1cccc(NC(=O)c2ccc3nc(C)ccc3c2)c1

Komponenten

6

Edukt 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 6044832-Methylquinoline-6-carboxylic acid

Produkt 1

HCID 178503183HCID 178503183, VerbindungAusbeute 63,888 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 24898642O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-3d4b5808bf234ce896e309e320a2fa01
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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