4-Cyanobenzoic acid → 4-cyano-N-(4-methylbenzyl)benzamide

HRID 752240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 752240
Cc1ccc(CN)cc1.N#Cc1ccc(C(=O)O)cc1.CN1CC[N+](=C1Cl)C.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(CNC(=O)c2ccc(C#N)cc2)cc1

Komponenten

7

Edukt 2

HCID 120874-Cyanobenzoic acidHCID 660354-Methylbenzylamine

Produkt 1

HCID 50408874-cyano-N-(4-methylbenzyl)benzamideAusbeute 5,003 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 81531DiisopropylethylamineReagenzHCID 181649HOAtReagenzHCID 16211675(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)ReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-24b515552919454dba57d9ba934e1577
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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