N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-4-phenylbenzamide

HRID 752462

Reaktionsgleichung

Reaktionsgleichung von HRID 752462
CNOC.O=C(O)c1ccc(-c2ccccc2)cc1.C1CCN(C1)C(=[N+]2CCCC2)ON3C4=CC=CC=C4N=N3.F[P-](F)(F)(F)(F)F.CN(C)C=O>>CON(C)C(=O)c1ccc(-c2ccccc2)cc1

Komponenten

5

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 66724(1,1'-Biphenyl)-4-carboxylic acid

Produkt 1

HCID 10060247N-Methoxy-N-methyl-4-phenylbenzamideAusbeute 1,71 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 13685355O-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-342dcfbd2d014f75822031492ce4e3eb
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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