Acetyl chloride → HCID 178418779, Verbindung

HRID 7532

Reaktionsgleichung

Reaktionsgleichung von HRID 7532
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH:10]1([N+:16]#[C-:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O.[C:25](Cl)(=[O:27])[CH3:26]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:25]([N+:1]1[C:23]([C:19]2[S:18][CH:22]=[CH:21][CH:20]=2)=[C:17]([NH:16][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]2[C:4]([NH2:9])=[CH:5][C:6]([Cl:8])=[N:7][C:2]=12)(=[O:27])[CH3:26]

Komponenten

6

Edukt 4

HCID 6367Acetyl chlorideHCID 73642-ThiophenecarboxaldehydeHCID 674322,4-Diamino-6-chloropyrimidineHCID 79129Cyclohexyl isocyanide

Produkt 1

HCID 178418779HCID 178418779, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24247Perchloric AcidLösungsmittel

Versuchsvorschrift

Example 26 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) thiophene-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Quellen und Nachweise

ORD-Eintrag
ord-2bfc1863edf9411185dcb4289134a90b
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087607B2

Verknüpfte Notizen

Wird geladen…