Acetyl chloride → HCID 178419001, Verbindung

HRID 7533

Reaktionsgleichung

Reaktionsgleichung von HRID 7533
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH3:10][O:11][C:12](=[O:16])[CH2:13][N+:14]#[C-:15].[CH:17](=O)[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1.[C:24](Cl)(=[O:26])[CH3:25]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:24]([N+:1]1[C:17]([C:18]2[O:22][CH:21]=[CH:20][CH:19]=2)=[C:15]([NH:14][CH2:13][C:12]([O:11][CH3:10])=[O:16])[N:3]2[C:4]([NH2:9])=[CH:5][C:6]([Cl:8])=[N:7][C:2]=12)(=[O:26])[CH3:25]

Komponenten

6

Edukt 4

HCID 6367Acetyl chlorideHCID 7362FurfuralHCID 674322,4-Diamino-6-chloropyrimidineHCID 547815Methyl isocyanoacetate

Produkt 1

HCID 178419001HCID 178419001, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24247Perchloric AcidLösungsmittel

Versuchsvorschrift

Example 27 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) isocyanoacetic acid methyl ester solution (0.2 M, DCM), 0.500 ml (0.15 mmol) furfural solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Quellen und Nachweise

ORD-Eintrag
ord-e09d80b009c94883976bbcd98164aff7
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087607B2

Verknüpfte Notizen

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