2-Chloro-6-methylpyridine-4-carboxylic acid → HCID 178498169, Verbindung
Reaktionsgleichung
COC(=O)c1ccc(N)cc1OC.Cc1cc(C(=O)O)cc(Cl)n1.COC1=NC(=NC(=N1)Cl)OC.CN1CCOCC1.CN(C)C=O>>COC(=O)c1ccc(NC(=O)c2cc(C)nc(Cl)c2)cc1OCKomponenten
6
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Reaktionsbedingungen
- Temperatur
- 25 °C
Aufarbeitung
- addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
- addition380 uL MeCN solvent were added to the transfer plate
- aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
- addition180 uL MeCN added to filter plate 1 for LCMS analysis
- aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
- addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
- customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM
Quellen und Nachweise
- ORD-Eintrag
- ord-7c47530b815943ff94f2284b650031a3
- Quelldatensatz
- AIChemEco amide coupling conditions 47k dataset
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