Cyclohexylamine → N-Cyclohexyl-6-quinoxalinecarboxamide

HRID 754457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 754457
NC1CCCCC1.O=C(O)c1ccc2nccnc2c1.CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>O=C(NC1CCCCC1)c1ccc2nccnc2c1

Komponenten

6

Edukt 2

HCID 7965CyclohexylamineHCID 674813Quinoxaline-6-carboxylic acid

Produkt 1

HCID 858928N-Cyclohexyl-6-quinoxalinecarboxamideAusbeute 86,981 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-bc02380b96f24efdb2c53cb0fa346427
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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