Cyclopentanecarbonyl chloride → N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

HRID 7545

Reaktionsgleichung

Reaktionsgleichung von HRID 7545
[NH2:1][CH:2]([C:5]1[C:6](=[O:15])[NH:7][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:16]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:11]([C:8]1[NH:7][C:6](=[O:15])[C:5]([CH:2]([NH:1][C:21]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:22])[CH2:3][CH3:4])=[N:10][N:9]=1)([CH3:14])([CH3:13])[CH3:12]

Komponenten

3

Edukt 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 1355940906-(1-Aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4h)-one

Produkt 1

HCID 135752563N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

Versuchsvorschrift

In analogy to the procedure for Example 36A, 110 mg (0.50 mmol) 6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one, 70 mg (0.50 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Aufarbeitung

  1. customThe crude product is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b46f015255f1488ebf4026b731b6fb22
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087605B2

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