Hydrazine hydrate (1:1) → HCID 178422720, Verbindung

HRID 75511

Reaktionsgleichung

Reaktionsgleichung von HRID 75511
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=O)[CH2:8][C:9](=O)[CH3:10])[CH:2]=1.O.[NH2:14][NH2:15]>CO>[CH3:10][C:9]1[CH:8]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[NH:14][N:15]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 3001601-(Pyridin-3-yl)butane-1,3-dione

Produkt 1

HCID 178422720HCID 178422720, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Pyridin-3-yl-butane-1,3-dione (step 1) (500 mg, 3.06 mmol) was dissolved in MeOH (20 ml). Hydrazine monohydrate (230 mg, 223 μl, 4.60 mmol) was added and the resulting mixture was stirred at RT for 1 hour. After cooling to RT, the solvent was removed in vacuo. The crude residue was dissolved in DCM, dried over (MgSO4) filtered and concentrated in vacuo to afford the title compound which was used without further purification.

Aufarbeitung

  1. temperatureAfter cooling to RT
  2. customthe solvent was removed in vacuo
  3. dissolutionThe crude residue was dissolved in DCM
  4. dry with materialdried over (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8ec2aed3230440bc91c59ac10514a757
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835444B2

Verknüpfte Notizen

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