Ethanol → 2-Oxopyrrolidine-3-carboxylic acid

HRID 76181

Reaktionsgleichung

Reaktionsgleichung von HRID 76181
C(OC([N:6]1[CH2:10][CH2:9][CH2:8][C:7]1=[O:11])=O)C.[OH-:12].[Na+].C[CH2:15][OH:16]>>[O:11]=[C:7]1[CH:8]([C:15]([OH:16])=[O:12])[CH2:9][CH2:10][NH:6]1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 234959Ethyl 2-oxopyrrolidine-1-carboxylate

Produkt 1

HCID 134743702-Oxopyrrolidine-3-carboxylic acid

Versuchsvorschrift

To 0.50 g (3.18 mmol) 2-oxo-pyrollidine-carboxylic acid ethyl ester in 10 mL EtOH are added 5 mL aq. NaOH (1M) solution. The reaction mixture is stirred at r.t. for 3 h. The EtOH is removed in vacuo and the residue is diluted with water and acidified with aq. HCl (2M) solution. The resulting precipitate is filtered and dried.

Aufarbeitung

  1. customThe EtOH is removed in vacuo
  2. additionthe residue is diluted with water
  3. filtrationThe resulting precipitate is filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-eb7275050f334e848da4cf494465570b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835472B2

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