Triethylamine → Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate

HRID 7632

Reaktionsgleichung

Reaktionsgleichung von HRID 7632
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(N(CC)CC)C>O1CCOCC1>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]([CH3:9])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 775312,4-DichloropyrimidineHCID 95849Glycine, N-methyl-, ethyl ester

Produkt 1

HCID 12056459Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

30.0 g (0.20 mol) of 2,4-dichloropyrimidine, 30.9 g (0.20 mol) of ethyl N-methylglycinate and 61.0 g (0.60 mol) of triethylamine in 200 ml of dioxane are stirred at 50° C. for 10 min. The mixture is filtered off with suction and the mother liquor is concentrated to half the original volume. A solid crystallizes out, which is filtered off with suction. The mother liquor is concentrated, the residue is stirred with petroleum ether and the product is filtered off.

Aufarbeitung

  1. filtrationThe mixture is filtered off with suction
  2. concentrationthe mother liquor is concentrated to half the original volume
  3. customA solid crystallizes out, which
  4. filtrationis filtered off with suction
  5. concentrationThe mother liquor is concentrated
  6. filtrationthe product is filtered off

Quellen und Nachweise

ORD-Eintrag
ord-8cdd1682398d44799c23b12882d311f3
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087616B2

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