Tetrahydrofuran → HCID 59406980, Verbindung

Reaktionsgleichung

[Si]([O:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2(CC(N)=O)[CH2:18][CH2:17]2)=[N:14][CH:15]=1)(C(C)(C)C)(C)C.[F-].[CH2:24]([N+:28](CCCC)(CCCC)CCCC)[CH2:25]CC.[O:41]1CCCC1>>[OH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2([NH:28][C:24](=[O:41])[CH3:25])[CH2:17][CH2:18]2)=[N:14][CH:15]=1

Komponenten

Edukt 3

HCID 8028Tetrahydrofuran2×

HCID 2724141Tetrabutylammonium Fluoride

HCID 684316481-[5-(Tert-butyldimethylsilanyloxymethyl)pyridin-2-yl]cyclopropylacetamide

Produkt 1

HCID 59406980HCID 59406980, Verbindung

Versuchsvorschrift

1-[5-(tert-Butyldimethylsilanyloxymethyl)pyridin-2-yl]cyclopropylacetamide (156 mg) was dissolved in tetrahydrofuran (2 ml), and a solution (1 mol/1, 1.46 ml) of tetrabutylammonium fluoride in tetrahydrofuran was added thereto. The mixture was stirred at room temperature for 25 min. The solvent was evaporated and the obtained residue was purified by column chromatography (Yamazen HI-FLASH™ COLUMN size L, elution solvent: ethyl acetate/methanol) to give the title compound (109 mg).