Sulfuryl chloride → 5-Fluoro-2-methoxy-3-(2-oxo-piperidin-1-yl)benzenesulfonyl chloride

Reaktionsgleichung

C(S[C:9]1[C:10]([O:23][CH3:24])=[C:11]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2=[O:22])[CH:12]=[C:13]([F:15])[CH:14]=1)C1C=CC=CC=1.[S:25]([Cl:29])(Cl)(=[O:27])=[O:26]>>[F:15][C:13]1[CH:12]=[C:11]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2=[O:22])[C:10]([O:23][CH3:24])=[C:9]([S:25]([Cl:29])(=[O:27])=[O:26])[CH:14]=1

Komponenten

Edukt 2

HCID 24648Sulfuryl chloride

HCID 669111631-(3-Benzylsulfanyl-5-fluoro-2-methoxy-phenyl)piperidin-2-one

Produkt 1

HCID 866532685-Fluoro-2-methoxy-3-(2-oxo-piperidin-1-yl)benzenesulfonyl chloride

Versuchsvorschrift

Intermediate 14 (1.6 g, 4.63 mmol) was converted to the title compound sulfonyl chloride using the procedure described in example 1; 1.6). The crude material was used without further purification in the next step.

Quellen und Nachweise

ORD-Eintrag: ord-92068e1b236f472f8792bddb3d9e6952
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08835653B2

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