Ammonium Hydroxide → 2-Amino-3,3-dimethylbutanoic acid

HRID 76845

Reaktionsgleichung

Reaktionsgleichung von HRID 76845
[OH-].[NH4+].[NH2:3][C@@H:4]([C:9]([OH:11])=[O:10])[C:5]([CH3:8])([CH3:7])[CH3:6]>CC(C)=O>[NH2:3][CH:4]([C:9]([OH:11])=[O:10])[C:5]([CH3:8])([CH3:7])[CH3:6]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 6950340D-tert-leucine

Produkt 1

HCID 3061312-Amino-3,3-dimethylbutanoic acidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

Ammonium hydroxide (50 mL, 30%) solution was placed in an autoclave and D-tert-leucine (5 g) was added. Autoclave was closed and the contents were heated to 85° C. under stirring for 12 hours. After cooling the solution was transferred and concentrated under vacuum at 55° C. The solid residue obtained was stirred with acetone (20 mL), filtered and dried to obtain DL-tert-leucine (4.6 g, 92% yield, L-isomer: 42%, D-isomer: 58%)

Aufarbeitung

  1. additionwas added
  2. customAutoclave was closed
  3. temperatureAfter cooling the solution
  4. concentrationconcentrated under vacuum at 55° C
  5. customThe solid residue obtained
  6. filtrationfiltered
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d453e83ed0824a199660d4e90a242ef9
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835676B2

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