Reaktionsgleichung
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:19])[C:17]#[N:18])=[C:12]([O:20][CH3:21])[CH:11]=1.O1C2C=CC=CC=2N=[C:23]1C1C=CC(C#N)=C(OC)C=1.ICC>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH2:19][CH3:23])[C:17]#[N:18])=[C:12]([O:20][CH3:21])[CH:11]=1Komponenten
4
Versuchsvorschrift
Utilizing the general procedure outlined in the synthesis of 2-[4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl]propanenitrile, 4-(1,3-benzoxazol-2-yl)-2-methoxybenzonitrile (300 mg, 1.1 mmol) was reacted with iodoethane (90 μL, 1.1 mmol) to afford the desired 2-[4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl]butanenitrile as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 7.87–7.84 (d, 1H), 7.79–7.74 (m, 2H), 7.59–7.53 (m, 2H), 7.37–7.34 (m, 2H), 4.22–4.17 (t, 1H), 3.97 (s, 3H), 1.95–1.89 (m, 2H), 1.13–1.08 (t, 3H). MS (ESI) 293 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-724a3c91a84f48bd9c3cc3b59fcaf0b0
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07087601B2
Verknüpfte Notizen
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