2-Aminophenol → N-(2-Hydroxyphenyl)-3-methoxy-4-methylbenzamide

HRID 7730

Reaktionsgleichung

Reaktionsgleichung von HRID 7730
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=O.S(Cl)(Cl)=O.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24].C(N(C(C)C)CC)(C)C>C1COCC1>[OH:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[NH:17][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:11]([CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=1

Komponenten

6

Edukt 4

HCID 58012-AminophenolHCID 24386Thionyl ChlorideHCID 81531DiisopropylethylamineHCID 815794-Methyl-m-anisic acid

Produkt 1

HCID 16378794N-(2-Hydroxyphenyl)-3-methoxy-4-methylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-Methoxy-4-methyl benzoic acid (1.2 g, 7.2 mmol) and thionyl chloride (10 mL) was heated to reflux conditions under argon until no starting material was observed by TLC. After cooling mixture to rt and concentration in vacuo, the resulting brown oil was dissolved in THF (15 mL) and slowly added to a cooled mixture of 2-aminophenol (780 mg, 7.1 mmol), diisopropylethyl amine (1.5 mL, 8.6 mmol) and THF (20 mL) at 0° C. Reaction mixture was allowed to warm to rt. After one hour, no starting material acid was observed by TLC. After concentrating reaction mixture in vacuo, the resulting brown oil was purified by flash chromatography on silica gel, using 1:4 EtOAc:hexanes. This afforded the desired intermediate, N-(2-hydroxyphenyl)-3-methoxy-4-methylbenzamide, as a yellow solid.

Aufarbeitung

  1. temperatureto reflux conditions under argon until no starting material
  2. concentrationconcentration in vacuo
  3. dissolutionthe resulting brown oil was dissolved in THF (15 mL)
  4. customReaction mixture
  5. temperatureto warm to rt
  6. concentrationAfter concentrating
  7. customreaction mixture in vacuo
  8. customthe resulting brown oil was purified by flash chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-f980798fac1b41878444490f8b753fdb
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087601B2

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